PAIN Alleviation of neuropathic pain by intrathecal injection of antisense oligonucleotides to p65 subunit of NF-kB
نویسندگان
چکیده
Methods. Lumbar intrathecal catheters were implanted in male Sprague–Dawley rats and a CCI model was established. Thermal and mechanical nociceptive thresholds were assessed with paw withdrawal latency (PWL) to radiant heat and von Frey filaments. The phosphorothioate-modified antisense ODNs to p65 subunit of NF-kB were administered intrathecally on each of five consecutive days post-CCI. Nuclear NF-kB p65 expression was assessed by western blot.
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